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Mouse Anti-PDCD10 Recombinant Antibody (4B10) (CBMAB-P1141-YC)

Provided herein is a Mouse monoclonal antibody against Human Programmed Cell Death 10. The antibody can be used for immunoassay techniques, such as ELISA.
See all PDCD10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B10
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
programmed cell death 10
Introduction
PDCD10 is an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Entrez Gene ID
11235
UniProt ID
Q9BUL8
Alternative Names
Programmed Cell Death 10; Cerebral Cavernous Malformations 3 Protein; TF-1 Cell Apoptosis-Related Protein 15; TFAR15; CCM3; Cerebral Cavernous Malformations 3; Programmed Cell Death Protein 10; Apoptosis-Related Protein 15;
Function
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006).
Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006).
Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Biological Process
AngiogenesisIEA:UniProtKB-KW
Cellular response to leukemia inhibitory factorIEA:Ensembl
Endothelium development1 PublicationIC:ComplexPortal
Establishment of Golgi localizationManual Assertion Based On ExperimentIMP:UniProtKB
Golgi reassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Intrinsic apoptotic signaling pathway in response to hydrogen peroxideManual Assertion Based On ExperimentIGI:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of Notch signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of angiogenesis1 PublicationIC:ComplexPortal
Regulation of Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Response to hydrogen peroxideManual Assertion Based On ExperimentIDA:UniProtKB
Wound healing, spreading of cellsManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Golgi apparatus membrane
Cell membrane
Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
Involvement in disease
Cerebral cavernous malformations 3 (CCM3):
A form of cerebral cavernous malformations, a congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. CCM3 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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