Mouse Anti-PDS5B Recombinant Antibody (2030D32a) (CBMAB-P1365-YC)

Name: Mouse Anti-PDS5B Recombinant Antibody (2030D32a)
SKU: CBMAB-P1365-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2030D32a

Application

Dot

Immunogen

Recombinant human Pds5, Regulator Of Cohesion Maintenance, Homolog B (S.Cerevisiae) (Pds5 B)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PDS5 Cohesin Associated Factor B

Introduction

PDS5B is a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.

Entrez Gene ID

23047

UniProt ID

Q9NTI5

Alternative Names

PDS5 Cohesin Associated Factor B; Androgen-Induced Proliferation Inhibitor; Androgen-Induced Prostate Proliferative Shutoff-Associated Protein AS3; APRIN; AS3; PDS5, Regulator Of Cohesion Maintenance, Homolog B (S. Cerevisiae);

Function

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

Biological Process

Cell divisionIEA:UniProtKB-KW
Cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell population proliferationManual Assertion Based On ExperimentIDA:MGI

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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