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Mouse Anti-PDSS2 Recombinant Antibody (1C11) (CBMAB-P1366-YC)

Provided herein is a Mouse monoclonal antibody against Human Decaprenyl Diphosphate Synthase Subunit 2. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all PDSS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Immunogen
Full length human recombinant protein of human PDSS2 produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Decaprenyl Diphosphate Synthase Subunit 2
Introduction
PDSS2 is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.
Entrez Gene ID
57107
UniProt ID
Q86YH6
Alternative Names
Decaprenyl Diphosphate Synthase Subunit 2; Prenyl (Decaprenyl) Diphosphate Synthase, Subunit 2; All-Trans-Decaprenyl-Diphosphate Synthase Subunit 2; Decaprenyl Pyrophosphate Synthase Subunit 2; C6orf210; DLP1; Decaprenyl Pyrophosphate Synthetase Subunit 2; Subunit 2 Of Decaprenyl Diphosphate Synthase;
Function
Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone (PubMed:16262699).
Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively (PubMed:16262699).
The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry (PubMed:16262699).
May play a role during cerebellar development (By similarity).
May regulate mitochondrial respiratory chain function (By similarity).
Biological Process
Cerebellum developmentISS:UniProtKB
Isoprenoid biosynthetic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Regulation of body fluid levelsIEA:Ensembl
Ubiquinone biosynthetic processManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Mitochondrion
Involvement in disease
Coenzyme Q10 deficiency, primary, 3 (COQ10D3):
A fatal encephalomyopathic form of coenzyme Q10 deficiency with nephrotic syndrome. Coenzyme Q10 deficiency is an autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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