Mouse Anti-PDX1 Recombinant Antibody (5A5) (CBMAB-0618CQ)

PDX1

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5-[CT]TAAT[TG]-3. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Animal organ regenerationIEA:Ensembl
Animal organ senescenceIEA:Ensembl
Central nervous system developmentIEA:Ensembl
Detection of glucoseISS:BHF-UCL
Digestive tract developmentIEA:Ensembl
Exocrine pancreas developmentIEA:Ensembl
Generation of precursor metabolites and energyManual Assertion Based On ExperimentTAS:ProtInc
Glucose homeostasisIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Insulin secretionManual Assertion Based On ExperimentIDA:BHF-UCL
Liver developmentIEA:Ensembl
Morphogenesis of embryonic epitheliumIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of type B pancreatic cell apoptotic processIEA:Ensembl
Nitric oxide mediated signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell deathIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to alkaloidIEA:Ensembl
Response to chlorateIEA:Ensembl
Response to cytokineIEA:Ensembl
Response to fatty acidIEA:Ensembl
Response to glucocorticoidIEA:Ensembl
Response to iron(II) ionIEA:Ensembl
Response to leucineIEA:Ensembl
Response to nicotineIEA:Ensembl
Response to vitaminIEA:Ensembl
Response to woundingIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Stem cell differentiationIEA:Ensembl
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
TransdifferentiationIEA:Ensembl
Type B pancreatic cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL

Nucleus
Cytoplasm, cytosol

Pancreatic agenesis 1 (PAGEN1):
A disease characterized by isolated hypoplasia or agenesis of the pancreas, pancreatic beta-cell failure resulting in neonatal insulin-dependent diabetes mellitus, and exocrine pancreatic insufficiency.
Diabetes mellitus, non-insulin-dependent (NIDDM):
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Maturity-onset diabetes of the young 4 (MODY4):
A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol (By similarity).