Mouse Anti-PDXK Recombinant Antibody (5H5) (CBMAB-P1381-YC)

Name: Mouse Anti-PDXK Recombinant Antibody (5H5)
SKU: CBMAB-P1381-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5H5

Application

FC, IF, IHC-P, WB

Immunogen

Full length human recombinant protein of human PDXK(NP_03672) produced in HEK293 cell.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

pyridoxal (pyridoxine, vitamin B6) kinase

Introduction

PDXK phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Entrez Gene ID

8566

UniProt ID

O00764

Alternative Names

Pyridoxal Kinase; Pyridoxal (Pyridoxine, Vitamin B6) Kinase; Pyridoxine Kinase; EC 2.7.1.35; C21orf124; C21orf97; PKH; PNK;

Function

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.

Biological Process

Pyridoxal 5'-phosphate salvageManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytosol

Involvement in disease

Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C):
An autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PDXK Recombinant Antibody (CBT3553) (CAT#: V2LY-0625-LY1930)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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