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Mouse Anti-PDXK Recombinant Antibody (5H5) (CBMAB-P1381-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyridoxal Kinase. The antibody can be used for immunoassay techniques, such as FC, IF, IHC-P, WB.
See all PDXK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5H5
Antibody Isotype
IgG2a
Application
FC, IF, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human PDXK(NP_03672) produced in HEK293 cell.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pyridoxal (pyridoxine, vitamin B6) kinase
Introduction
PDXK phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Entrez Gene ID
8566
UniProt ID
O00764
Alternative Names
Pyridoxal Kinase; Pyridoxal (Pyridoxine, Vitamin B6) Kinase; Pyridoxine Kinase; EC 2.7.1.35; C21orf124; C21orf97; PKH; PNK;
Function
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Biological Process
Pyridoxal 5'-phosphate salvageManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Involvement in disease
Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C):
An autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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