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PDXK

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Full Name

pyridoxal (pyridoxine, vitamin B6) kinase

Function

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:9099727, PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503) (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.

Biological Process

Pyridoxal 5'-phosphate salvageManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytosol

Involvement in disease

Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C):
An autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment.

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Anti-PDXK antibodies

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Mouse Anti-PDXK Recombinant Antibody (5H5) (CBMAB-P1381-YC)

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Target: PDXK

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5H5

Application*: F, IF, P, WB

Mouse Anti-PDXK Recombinant Antibody (4G6) (CBMAB-P1380-YC)

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Target: PDXK

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4G6

Application*: E, WB

Mouse Anti-PDXK Recombinant Antibody (3G2) (CBMAB-P1379-YC)

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Target: PDXK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3G2

Application*: F, IH, WB

Mouse Anti-PDXK Recombinant Antibody (CBT3553) (V2LY-0625-LY1930)

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Target: PDXK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBT3553

Application*: WB, IH, IC, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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