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Mouse Anti-PDXP Recombinant Antibody (H-5) (CBMAB-P1383-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyridoxal Phosphatase. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PDXP antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
H-5
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyridoxal Phosphatase
Introduction
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP.
Entrez Gene ID
Human57026
Mouse57028
Rat727679
UniProt ID
HumanQ96GD0
MouseP60487
RatQ8VD52
Alternative Names
CIN; PLP; dJ37E16.5
Function
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP> PNP> PMP and therefore plays a role in vitamin B6 metabolism (PubMed:14522954, PubMed:8132548).
Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (PubMed:15580268).
Biological Process
Actin rod assemblyManual Assertion Based On ExperimentIDA:MGI
Cellular response to ATPManual Assertion Based On ExperimentIDA:MGI
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of actin filament depolymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Pyridoxal phosphate catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytosol
Cytoplasm, cytoskeleton
Cell projection, ruffle membrane
Cell projection, lamellipodium membrane
Cell membrane
Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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