Mouse Anti-PDZK1 Recombinant Antibody (V2-357401) (CBMAB-P1391-YC)

Name: Mouse Anti-PDZK1 Recombinant Antibody (V2-357401)
SKU: CBMAB-P1391-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

V2-357401

Application

WB, FC, ELISA, ICC, IF

Immunogen

Recombinant human PDZK1 (1-519aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PDZ domain containing 1

Introduction

PDZK1 is a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1.

Entrez Gene ID

5174

UniProt ID

Q5T2W1

Alternative Names

PDZ Domain Containing 1; Na/Pi Cotransporter C-Terminal-Associated Protein 1; Sodium-Hydrogen Exchanger Regulatory Factor 3; CFTR-Associated Protein Of 70 KDa; NaPi-Cap1; NHERF-3; NHERF3; CAP70;

Function

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).

Biological Process

Carnitine transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cation transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of ion transmembrane transporter activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein targeting to membraneISS:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Regulation of anion transportISS:UniProtKB
Xenobiotic detoxification by transmembrane export across the plasma membrane1 PublicationNAS:UniProtKB

Cellular Location

Membrane
Cell membrane
Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PDZK1 Recombinant Antibody (1C3-2B11) (CAT#: CBMAB-P1392-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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