Sign in or Register   Sign in or Register
  |  

Mouse Anti-PEG3 Recombinant Antibody (1F12) (CBMAB-P1429-YC)

Provided herein is a Mouse monoclonal antibody against Human Paternally Expressed 3. The antibody can be used for immunoassay techniques, such as WB.
See all PEG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F12
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-364 of human PEG3 (NP_006201) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-364

Target

Full Name
Paternally Expressed 3
Introduction
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
5178
UniProt ID
Q9GZU2
Alternative Names
Paternally Expressed 3; Zinc Finger And SCAN Domain-Containing Protein 24; ZSCAN24; Paternally-Expressed Gene 3 Protein; Kruppel-Type Zinc Finger Protein; ZKSCAN22; KIAA0287; ZNF904; PW1;
Function
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity).
Possesses a tumor suppressing activity in glioma cells.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Regulation of gene expressionISS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PEG3 Recombinant Antibody (1F12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare