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Mouse Anti-PGAP1 Recombinant Antibody (5G6) (CBMAB-A6596-LY)

The product is antibody recognizes PGAP1. The antibody 5G6 immunoassay techniques such as: sELISA, ELISA.
See all PGAP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5G6
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
PGAP1 (NP_079265, 168 a.a. ~ 266 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
post-GPI attachment to proteins 1
Introduction
PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM
Entrez Gene ID
80055
UniProt ID
Q75T13
Alternative Names
Bst1; FLJ42774; ISPD3024
Function
Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).
Biological Process
Anterior/posterior axis specificationIEA:Ensembl
Attachment of GPI anchor to proteinTAS:Reactome
Embryonic pattern specificationIEA:Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Forebrain regionalizationIEA:Ensembl
GPI anchor metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ER to Golgi vesicle-mediated transportISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Sensory perception of soundIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Mental retardation, autosomal recessive 42 (MRT42):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Topology
Cytoplasmic: 1-11
Helical: 12-32
Lumenal: 33-641
Helical: 642-662
Cytoplasmic: 663-668
Helical: 669-689
Lumenal: 690-733
Helical: 734-754
Cytoplasmic: 755-817
Helical: 818-838
Lumenal: 839-853
Helical: 854-874
Cytoplasmic: 875-893
Helical: 894-914
Lumenal: 915-922
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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