Mouse Anti-PGAP1 Recombinant Antibody (5G6) (CBMAB-A6596-LY)

Name: Mouse Anti-PGAP1 Recombinant Antibody (5G6)
SKU: CBMAB-A6596-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5G6

Application

sELISA, ELISA

Immunogen

PGAP1 (NP_079265, 168 a.a. ~ 266 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

post-GPI attachment to proteins 1

Introduction

PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM

Entrez Gene ID

80055

UniProt ID

Q75T13

Alternative Names

Bst1; FLJ42774; ISPD3024

Function

Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi (By similarity).

Biological Process

Anterior/posterior axis specificationIEA:Ensembl
Attachment of GPI anchor to proteinTAS:Reactome
Embryonic pattern specificationIEA:Ensembl
Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Forebrain regionalizationIEA:Ensembl
GPI anchor metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ER to Golgi vesicle-mediated transportISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Sensory perception of soundIEA:Ensembl

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Mental retardation, autosomal recessive 42 (MRT42):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

Topology

Cytoplasmic: 1-11
Helical: 12-32
Lumenal: 33-641
Helical: 642-662
Cytoplasmic: 663-668
Helical: 669-689
Lumenal: 690-733
Helical: 734-754
Cytoplasmic: 755-817
Helical: 818-838
Lumenal: 839-853
Helical: 854-874
Cytoplasmic: 875-893
Helical: 894-914
Lumenal: 915-922

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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