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Mouse Anti-PGBD5 Recombinant Antibody (CBYC-P320) (CBMAB-P1560-YC)

Provided herein is a Mouse monoclonal antibody against Human PiggyBac Transposable Element Derived 5. The antibody can be used for immunoassay techniques, such as WB, IHC, IF, ICC.
See all PGBD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYC-P320
Antibody Isotype
IgG1
Application
WB, IHC, IF, ICC

Basic Information

Immunogen
A synthetic peptide (conjugated with KLH) corresponding to the human PGBD5
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
TBS, pH 7.4, 0.5% BSA, 40% glycerol and 0.05% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PiggyBac Transposable Element Derived 5
Introduction
The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families.
Entrez Gene ID
Human79605
Mouse209966
UniProt ID
HumanQ8N414
MouseD3YZI9
Alternative Names
PiggyBac Transposable Element Derived 5; PiggyBac Domain-Related Protein 5; PiggyBac Transposase 5; EC 3.1.-.-;
Function
Transposase that mediates sequence-specific genomic rearrangements (PubMed:26406119, PubMed:28504702).
Can induce genomic rearrangements that inactivate the HPRT1 gene (PubMed:27491780).
Biological Process
Non-replicative transposition, DNA-mediatedManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Induces site-specific DNA rearrangements, including intrachromosomal deletions, as well as inversions, duplications and translocations, in rhabdoid tumors that share developmental origin with cells that normally express PGBD5, even though these tumors may not exhibit apparent widespread genomic instability. This activity recurrently targets regulatory elements and tumor suppressor genes and promotes cell transformation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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