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Mouse Anti-PHF2 Recombinant Antibody (CBLG1-2402) (CBMAB-G6448-LY)

This product is antibody recognizes PHF2. The antibody CBLG1-2402 immunoassay techniques such as: WB.
See all PHF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2402
Antibody Isotype
IgM
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PHD Finger Protein 2
Introduction
This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
PHD Finger Protein 2; Jumonji C Domain-Containing Histone Demethylase 1E; Centromere Protein 35; CENP-35; GRC5; Lysine-Specific Demethylase PHF2;
Function
Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585).
Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585).
Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585).
The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585).
Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity).
Biological Process
Epigenetic maintenance of chromatin in transcription-competent conformationISS:UniProtKB
Histone H4-K20 demethylationISS:UniProtKB
Liver developmentManual Assertion Based On ExperimentTAS:UniProtKB
Negative regulation of ribosomal DNA heterochromatin assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nucleolus
Chromosome, centromere, kinetochore
PTM
Phosphorylated by PKA on specific serine residues, leading to the formation of an active lysine demethylase complex.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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