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Mouse Anti-PHF21A Recombinant Antibody (5A6) (CBMAB-P1662-YC)

Provided herein is a Mouse monoclonal antibody against Human PHD Finger Protein 21A. The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all PHF21A antibodies
Published Data
Fig.1 Western blot showing PHF21A protein levels in patient and mother.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
5A6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PHD finger protein 21A
Introduction
The PHF21A gene encodes BHC80, a component of a BRAF35/histone deacetylase complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS).
Entrez Gene ID
51317
UniProt ID
Q96BD5
Alternative Names
PHD Finger Protein 21A; BRAF35-HDAC Complex Protein BHC80; BHC80a; BHC80; BRAF35/HDAC2 Complex (80 KDa); KIAA1696; BM-006;
Function
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
Involvement in disease
Intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures (IDDBCS):
An autosomal dominant neurodevelopmental disorder characterized by impaired intellectual development, developmental delay of varying severity, impaired motor skills and language delay. Additional clinical features include macrocephaly, obesity, overgrowth, craniofacial dysmorphism, epilepsy, and variable behavioral manifestations including autism and attention deficit hyperactivity disorder.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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