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Mouse Anti-PHLDA3 Recombinant Antibody (4B6) (CBMAB-P1695-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleckstrin Homology Like Domain Family A Member 3. The antibody can be used for immunoassay techniques, such as WB.
See all PHLDA3 antibodies
Published Data
Fig.1 MM468 cells were transduced with Ad-LacZ or Ad-p53 at moi 15 and harvested 18 hr post-infection.
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Fig.2 Cell spreading is not inhibited by PHLDA3.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B6
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pleckstrin Homology Like Domain Family A Member 3
Introduction
PHLDA3 has broad expression in fat (RPKM 24.2), esophagus (RPKM 11.1) and 22 other tissues.
Entrez Gene ID
23612
UniProt ID
Q9Y5J5
Alternative Names
Pleckstrin Homology Like Domain Family A Member 3; Pleckstrin Homology-Like Domain, Family A, Member 2; TDAG51/Ipl Homolog 1; TIH1; Pleckstrin Homology-Like Domain, Family A, Member 3; Pleckstrin Homology-Like Domain Family A Member 3;
Function
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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