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Recombinant Rabbit Anti-Phospho-AKT1-S473 Antibody (CBAb256) (CBMAB-Ab256-LY)

The product is antibody recognizes Phospho-AKT1-S473. The antibody immunoassay techniques such as: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:100-1:500.
Host Species
Rabbit
Application
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:100-1:500
Immunogen
A phospho specific peptide corresponding to residues surrounding S473 of human Akt1
Antibody Isotype
IgG
Specificity
Human
Cross Reactivity
Human, Mouse, Rat
Clone
CBAb256
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Alternative Name
AKT1; AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA; AKT serine/threonine kinase 1
Entrez Gene ID
UniProt ID
Cat CBMAB-Ab256-LY
Conjugates
Size
Price $
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