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Rabbit Anti-Phospho-CAD (Ser1859) Recombinant Antibody (D5O6C) (CBMAB-CP0063-LY)

The product is antibody recognizes Phospho-CAD (Ser1859). The antibody D5O6C immunoassay techniques such as: WB,IF (ICC).
See all Phospho-CAD (Ser1859) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D5O6C
Antibody Isotype
IgG
Application
WB, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1859 of human CAD protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase
Introduction
CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase) is a Protein Coding gene. Diseases associated with CAD include Epileptic Encephalopathy, Early Infantile, 50. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and enzyme binding. An important paralog of this gene is CPS1.
Entrez Gene ID
Human790
Mouse69719
Rat24240
UniProt ID
HumanP27708
MouseB2RQC6
RatD4A8A0
Alternative Names
Carbamoyl-Phosphate Synthetase 2; Aspartate Transcarbamylase; And Dihydroorotase; Multifunctional Protein CAD; CAD Trifunctional Protein; CAD Protein; EC 6.3.5.5; EC 2.1.3.2;
Function
This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Biological Process
de novo' pyrimidine nucleobase biosynthetic process Source: UniProtKB
'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Animal organ regeneration Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to epidermal growth factor stimulus Source: Ensembl
Citrulline biosynthetic process Source: GO_Central
Drug metabolic process Source: BHF-UCL
Female pregnancy Source: Ensembl
Glutamine metabolic process Source: BHF-UCL
Heart development Source: Ensembl
Lactation Source: Ensembl
Liver development Source: Ensembl
Nitrogen compound metabolic process Source: GO_Central
Peptidyl-threonine phosphorylation Source: BHF-UCL
Protein autophosphorylation Source: BHF-UCL
Pyrimidine nucleoside biosynthetic process Source: Reactome
Response to amine Source: Ensembl
Response to caffeine Source: Ensembl
Response to cortisol Source: Ensembl
Response to insulin Source: Ensembl
Response to starvation Source: Ensembl
Response to testosterone Source: Ensembl
UTP biosynthetic process Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Involvement in disease
Developmental and epileptic encephalopathy 50 (DEE50): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE50 is an autosomal recessive, progressive disease with onset in infancy and favorable response to treatment with oral uridine.
PTM
Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivity to feedback inhibition by UTP.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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