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Rabbit Anti-Phospho-CDCP1 (Tyr743) Recombinant Antibody (D2G2J) (CBMAB-CP0255-LY)

The product is antibody recognizes Phospho-CDCP1 (Tyr743). The antibody D2G2J immunoassay techniques such as: WB.
See all Phospho-CDCP1 (Tyr743) antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D2G2J
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr743 of human CDCP1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CUB Domain Containing Protein 1
Introduction
CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with CDCP1 include Colorectal Cancer. Among its related pathways are Wnt / Hedgehog / Notch and NF-kappaB Signaling.
Entrez Gene ID
UniProt ID
Alternative Names
CUB Domain Containing Protein 1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; Transmembrane And Associated With Src Kinases; Membrane Glycoprotein Gp140; SIMA135; TRASK; CUB Domain-Containing Protein 1; CD318 Antigen; CD318;
Function
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Cellular Location
Isoform 1: Cell membrane. Shedding may also lead to a soluble peptide.
Isoform 3: Secreted
Topology
Extracellular: 30-667
Helical: 668-688
Cytoplasmic: 689-836
PTM
Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
N-glycosylated.
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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