|  

Rabbit Anti-Phospho-DCX (Ser334) Recombinant Antibody (D11B10) (CBMAB-CP0495-LY)

The product is antibody recognizes Phospho-DCX (Ser334). The antibody D11B10 immunoassay techniques such as: WB,IF,IF (ICC).
Host Animal
Rabbit
Application
WB, IF, IF (ICC)
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser334 of mouse doublecortin protein.
Antibody Isotype
IgG
Cross Reactivity
Mouse, Rat, Human
Clone
D11B10
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Alternative Name
Doublecortin; Lissencephalin-X; Doublecortex; Doublin; Lis-X; DBCN; LISX;
Entrez Gene ID
UniProt ID