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Rabbit Anti-Phospho-FOXM1 (Thr600) Recombinant Antibody (D9M6G) (CBMAB-CP0743-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
D9M6G
Application
WB, IP
Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr600 of human FoxM1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Forkhead Box M1
Introduction
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Entrez Gene ID
2305
UniProt ID
Q08050
Alternative Names
Forkhead Box M1; M-Phase Phosphoprotein 2; Hepatocyte Nuclear Factor 3 Forkhead Homolog 11; Winged-Helix Factor From INS-1 Cells; Forkhead-Related Protein FKHL16; MPM-2 Reactive Phosphoprotein 2; Transcription Factor Trident; HNF-3/Fork-Head Homolog 11; FKHL16; HFH-11; HFH11; MPP2;
Function
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
DNA repair Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Negative regulation of cell aging Source: UniProtKB
Negative regulation of stress-activated MAPK cascade Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of double-strand break repair Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cell cycle Source: BHF-UCL
Regulation of cell growth Source: UniProtKB
Regulation of cell population proliferation Source: GO_Central
Regulation of Ras protein signal transduction Source: BHF-UCL
Regulation of reactive oxygen species metabolic process Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
PTM
Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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