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Rabbit Anti-Phospho-PLCG1 (Ser1248) Recombinant Antibody (D25A9) (CBMAB-CP2014-LY)


See all Phospho-PLCG1 (Ser1248) antibodies
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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Rat
Clone
D25A9
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF (ICC), FC

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1248 of human PLCγ1 protein.
Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phospho-PLCG1 (Ser1248)
Entrez Gene ID
Human5335
Mouse18803
Rat25738
Monkey697069
UniProt ID
HumanP19174
MouseQ62077
RatP10686
MonkeyA0A1D5R8E9
Function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).
Plays a role in actin reorganization and cell migration (PubMed:17229814).
Biological Process
Calcium-mediated signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Fc-epsilon receptor signaling pathwayTAS:Reactome
Negative regulation of inflammatory response to antigenic stimulusTAS:Reactome
Phosphatidylinositol metabolic processISS:UniProtKB
Phospholipid catabolic processIEA:InterPro
Positive regulation of angiogenesisManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of epithelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of release of sequestered calcium ion into cytosolManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
T cell receptor signaling pathwayTAS:Reactome
Cellular Location
Cell projection, lamellipodium
Cell projection, ruffle
Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
PTM
Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity).
Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.
Ubiquitinated by CBLB in activated T-cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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