WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
A phospho specific peptide corresponding to residues surrounding S807 of human Rb
Human, Mouse, Rat
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
RB1; OSRC; PPP1R130; RB; p105-Rb; pRb; pp110; RB transcriptional corepressor 1