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Rabbit Anti-Phospho-REPS1 (Ser709) Recombinant Antibody (D8C1) (CBMAB-CP2248-LY)

The product is antibody recognizes Phospho-REPS1 (Ser709). The antibody D8C1 immunoassay techniques such as: WB,IP.
See all Phospho-REPS1 (Ser709) antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D8C1
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser709 of human REPS1 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RALBP1 Associated Eps Domain Containing 1
Introduction
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Entrez Gene ID
Human85021
Monkey702858
UniProt ID
HumanQ96D71
MonkeyG7MQ88
Alternative Names
RALBP1 Associated Eps Domain Containing 1; RalBP1-Interacting Protein 1; RalBP1-Associated Eps Domain-Containing Protein 1; RalBP1;
Function
May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
Biological Process
EndocytosisManual Assertion Based On ExperimentIBA:GO_Central
Endosomal transportManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisIEA:InterPro
Cellular Location
Membrane, clathrin-coated pit
Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Involvement in disease
Neurodegeneration with brain iron accumulation 7 (NBIA7):
A neurodegenerative disorder associated with iron accumulation, primarily in the basal ganglia. Clinical features include speech and motor delay, truncal hypotonia, progressive cerebellar ataxia, and loss of ambulation. NBIA7 transmission pattern is consistent with autosomal recessive inheritance.
PTM
EGF stimulates phosphorylation on Tyr-residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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