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Mouse Anti-PIF1 Recombinant Antibody (F-10) (CBMAB-P1754-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
F-10
Antibody Isotype
IgG
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PIF1 5'-To-3' DNA Helicase
Introduction
PIF1 is a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus.
Entrez Gene ID
Human80119
Mouse208084
Rat367645
UniProt ID
HumanQ9H611
MouseQ80SX8
RatQ1HG60
Alternative Names
PIF1 5'-To-3' DNA Helicase; PIF1 5-To-3 DNA Helicase; DNA Repair And Recombination Helicase PIF1; PIF1/RRM3 DNA Helicase-Like Protein; C15orf20; PIF1 5-To-3 DNA Helicase Homolog (S. Cerevisiae); Chromosome 15 Open Reading Frame 20;
Function
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
Biological Process
DNA duplex unwindingManual Assertion Based On ExperimentIBA:GO_Central
DNA recombinationIEA:UniProtKB-UniRule
DNA repairIEA:UniProtKB-UniRule
DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Mitochondrial genome maintenanceIEA:UniProtKB-UniRule
Negative regulation of telomerase activityManual Assertion Based On ExperimentIDA:HGNC-UCL
Negative regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of telomere maintenanceManual Assertion Based On ExperimentIDA:HGNC-UCL
Telomere maintenance via telomeraseTAS:Reactome
Cellular Location
Nucleus
Isoform 4
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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