Mouse Anti-PIGH Recombinant Antibody (2F8) (CBMAB-P1758-YC)

Name: Mouse Anti-PIGH Recombinant Antibody (2F8)
SKU: CBMAB-P1758-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F8

Application

ELISA, WB

Immunogen

PIGH (NP_004560, 89-188 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphatidylinositol glycan anchor biosynthesis, class H

Introduction

PIGH is an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.

Entrez Gene ID

5283

UniProt ID

Q14442

Alternative Names

Phosphatidylinositol Glycan Anchor Biosynthesis Class H; PIG-H; Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit H; Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit; Phosphatidylinositol-Glycan Biosynthesis, Class H Protein; Phosphatidylinositol-Glycan Biosynthesis Class H Protein; Phosphatidylinositol Glycan, Class H; EC 2.4.1.198; GPI-H;

Function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.

Biological Process

Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
GPI anchor biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Glycosylphosphatidylinositol biosynthesis defect 17 (GPIBD17):
An autosomal recessive disorder characterized by variable neurologic deficits that become apparent in infancy or early childhood. Clinical features include learning disabilities, mild-to-moderate developmental delay, seizures of variable severity, aggressive or over-friendly behavior, and autistic features.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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