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Mouse Anti-PIGH Recombinant Antibody (2F8) (CBMAB-P1758-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class H. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PIGH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PIGH (NP_004560, 89-188 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class H
Introduction
PIGH is an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. The protein encoded by this gene is a subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum.
Entrez Gene ID
5283
UniProt ID
Q14442
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class H; PIG-H; Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit H; Phosphatidylinositol N-Acetylglucosaminyltransferase Subunit; Phosphatidylinositol-Glycan Biosynthesis, Class H Protein; Phosphatidylinositol-Glycan Biosynthesis Class H Protein; Phosphatidylinositol Glycan, Class H; EC 2.4.1.198; GPI-H;
Function
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Biological Process
Cellular protein modification processManual Assertion Based On ExperimentTAS:ProtInc
GPI anchor biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Glycosylphosphatidylinositol biosynthesis defect 17 (GPIBD17):
An autosomal recessive disorder characterized by variable neurologic deficits that become apparent in infancy or early childhood. Clinical features include learning disabilities, mild-to-moderate developmental delay, seizures of variable severity, aggressive or over-friendly behavior, and autistic features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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