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Mouse Anti-PIGP Recombinant Antibody (2E7) (CBMAB-P1762-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class P. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PIGP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class P
Introduction
PIGP is an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
51227
UniProt ID
P57054
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class P; Phosphatidylinositol-N-Acetylglucosaminyltranferase Subunit; Phosphatidylinositol-Glycan Biosynthesis Class P Protein; Down Syndrome Critical Region Protein 5; Down Syndrome Critical Region Protein C; Down Syndrome Critical Region Gene 5; Phosphatidylinositol Glycan, Class P; DSCR5; PIG-P;
Function
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Biological Process
GPI anchor biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Involvement in disease
Developmental and epileptic encephalopathy 55 (DEE55):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE55 is an autosomal recessive condition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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