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Mouse Anti-PIGQ Recombinant Antibody (2B7) (CBMAB-P1763-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphatidylinositol Glycan Anchor Biosynthesis Class Q. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PIGQ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B7
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
PIGQ (NP_683721.1, 661-758 aa) partial recombinant protein with GST tag. Immunogen sequence: HCPMPTLCTQ VQRVRPPQQP QVEGWSPWGL PSGSALAVGV EGPCQDEPPS PRHPLAPSAE QHPASGGLKQ SLTPVPSGPG PSLPEPHGVY LRMFPGEV
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 661-758

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class Q
Introduction
PIGQ is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).
Entrez Gene ID
9091
UniProt ID
Q9BRB3
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class Q; Phosphatidylinositol-Glycan Biosynthesis Class Q Protein; N-Acetylglucosamyl Transferase Component GPI1; Phosphatidylinositol Glycan, Class Q; PIG-Q; GPI1;
Function
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
Biological Process
Carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
GPI anchor biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Involvement in disease
Multiple congenital anomalies-hypotonia-seizures syndrome 4 (MCAHS4):
An autosomal recessive syndrome characterized by onset of refractory seizures in the first months of life. Additional clinical features include severe global developmental delay, dysmorphic facial features, and skeletal, renal and ophthalmic anomalies. At the cellular level, the disorder is caused by a defect in the synthesis of glycosylphosphatidylinositol (GPI).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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