Mouse Anti-PIGQ Recombinant Antibody (2B7) (CBMAB-P1763-YC)

Name: Mouse Anti-PIGQ Recombinant Antibody (2B7)
SKU: CBMAB-P1763-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B7

Application

ELISA, IHC-P, WB

Immunogen

PIGQ (NP_683721.1, 661-758 aa) partial recombinant protein with GST tag. Immunogen sequence: HCPMPTLCTQ VQRVRPPQQP QVEGWSPWGL PSGSALAVGV EGPCQDEPPS PRHPLAPSAE QHPASGGLKQ SLTPVPSGPG PSLPEPHGVY LRMFPGEV

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 661-758

More Infomation

Target

Full Name

phosphatidylinositol glycan anchor biosynthesis, class Q

Introduction

PIGQ is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).

Entrez Gene ID

9091

UniProt ID

Q9BRB3

Alternative Names

Phosphatidylinositol Glycan Anchor Biosynthesis Class Q; Phosphatidylinositol-Glycan Biosynthesis Class Q Protein; N-Acetylglucosamyl Transferase Component GPI1; Phosphatidylinositol Glycan, Class Q; PIG-Q; GPI1;

Function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.

Biological Process

Carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
GPI anchor biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane

Involvement in disease

Multiple congenital anomalies-hypotonia-seizures syndrome 4 (MCAHS4):
An autosomal recessive syndrome characterized by onset of refractory seizures in the first months of life. Additional clinical features include severe global developmental delay, dysmorphic facial features, and skeletal, renal and ophthalmic anomalies. At the cellular level, the disorder is caused by a defect in the synthesis of glycosylphosphatidylinositol (GPI).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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