Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PIGT Recombinant Antibody (2A2) (CBMAB-P1771-YC)


See all PIGT antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A2
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
PIGT (NP_057021.2, 24-123 aa) partial recombinant protein with GST tag. Immunogen sequence: EPPRDSLREE LVITPLPSGD VAATFQFRTR WDSELQREGV SHYRLFPKAL GQLISKYSLR ELHLSFTQGF WRTRYWGPPF LQAPSGAELW VWFQDTVTDV
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 24-123

Target

Full Name
phosphatidylinositol glycan anchor biosynthesis, class T
Introduction
PIGT is a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Entrez Gene ID
51604
UniProt ID
Q969N2
Alternative Names
Phosphatidylinositol Glycan Anchor Biosynthesis Class T; Phosphatidylinositol-Glycan Biosynthesis Class T Protein; GPI Transamidase Subunit; Neurotrophin-Regulated Neuronal Development-Associated Protein; Phosphatidylinositol Glycan, Class T; GPI Transamidase Component PIG-T;
Function
Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
Biological Process
Attachment of GPI anchor to proteinManual Assertion Based On ExperimentIBA:GO_Central
Neuron apoptotic processIEA:Ensembl
Neuron differentiationIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Multiple congenital anomalies-hypotonia-seizures syndrome 3 (MCAHS3):
An autosomal recessive syndrome characterized by distinct facial features, intellectual disability, hypotonia and seizures, in combination with abnormal skeletal, endocrine, and ophthalmologic findings including impaired vision, as well as abnormal motility of the eyes.
Paroxysmal nocturnal hemoglobinuria 2 (PNH2):
A disorder characterized by hemolytic anemia with hemoglobinuria, thromboses in large vessels, and a deficiency in hematopoiesis. Red blood cell breakdown with release of hemoglobin into the urine is manifested most prominently by dark-colored urine in the morning.
Topology
Lumenal: 22-527
Helical: 528-548
Cytoplasmic: 549-578
PTM
The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PIGT Recombinant Antibody (2A2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry