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Mouse Anti-PITX1 Recombinant Antibody (6D4) (CBMAB-A6728-LY)

The product is antibody recognizes PITX1. The antibody 6D4 immunoassay techniques such as: WB, ELISA.
See all PITX1 antibodies
Published Data
Fig. 1 Cell lysates were subjected to immunoblot analysis with anti-Pitx1 or antitubulin.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6D4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PITX1 (NP_002644, 225 a.a. ~ 313 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
paired-like homeodomain 1
Introduction
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq]
Entrez Gene ID
5307
Alternative Names
BFT; POTX; PTX1
Function
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
Biological Process
Anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Branchiomeric skeletal muscle developmentIEA:Ensembl
Cartilage developmentIEA:Ensembl
Embryonic hindlimb morphogenesisIEA:Ensembl
Myoblast fate commitmentIEA:Ensembl
Negative regulation of transcription, DNA-templatedIEA:Ensembl
Pituitary gland developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Skeletal system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF):
A congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e., inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Some patients present tibial hemimelia, bilateral patellar hypoplasia, and preaxial mirror-image polydactyly.
Liebenberg syndrome (LBNBG):
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving the PITX1 locus results in LBNBG. Translocation t(5;18)(q31.1;q12.3). Additionally, two chromosome 5 deletions located 5'of PITX1 have been found in LBNBG patients. These structural variations cause altered expression of PITX1 in the forelimb via the activation of ectopic enhancers (PubMed:23022097).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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