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Mouse Anti-PKD2L1 Recombinant Antibody (4F9) (CBMAB-P1921-YC)

Provided herein is a Mouse monoclonal antibody against Human Polycystin 2 Like 1, Transient Receptor Potential Cation Channel. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PKD2L1 antibodies
Published Data
Fig. 1 Detection of PKD2L1 in mouse kidney, testis, and brain tissues by WB.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F9
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PKD2L1 (NP_057196.2, 173-272 aa) partial recombinant protein with GST tag. Immunogen sequence: KWYNNQSLGH GSHSFIYYEN MLLGVPRLRQ LKVRNDSCVV HEDFREDILS CYDVYSPDKE EQLPFGPFNG TAWTYHSQDE LGGFSHWGRL TSYSGGGYYL
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 173-272

Target

Full Name
polycystic kidney disease 2-like 1
Introduction
PKD2L1 is a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N-and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel.
Entrez Gene ID
9033
UniProt ID
Q9P0L9
Alternative Names
TRPP3; PCL; PKD2L; PKDL
Function
Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca2+ (PubMed:10517637, PubMed:11959145, PubMed:25820328, PubMed:27754867, PubMed:29425510, PubMed:23212381, PubMed:30004384).
Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration (PubMed:24336289).
The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription (PubMed:24336289).
Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells (PubMed:19812697).
The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again (PubMed:23212381).
May play a role in the perception of carbonation taste (By similarity).
May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity).
Biological Process
Cation transportISS:BHF-UCL
Cellular response to acidic pHISS:BHF-UCL
Detection of chemical stimulus involved in sensory perception of sour tasteISS:BHF-UCL
Detection of chemical stimulus involved in sensory perception of tasteISS:UniProtKB
Detection of mechanical stimulusManual Assertion Based On ExperimentIBA:GO_Central
Inorganic cation transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Response to waterIEA:Ensembl
Sensory perception of sour tasteManual Assertion Based On ExperimentIMP:UniProtKB
Smoothened signaling pathwayISS:UniProtKB
Sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cell projection, cilium membrane
Cell membrane
Cytoplasmic vesicle
Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.
Topology
Cytoplasmic: 1-103
Helical: 104-124
Extracellular: 125-356
Helical: 357-376
Cytoplasmic: 377-384
Helical: 385-405
Extracellular: 406-433
Helical: 434-454
Cytoplasmic: 455-479
Helical: 480-499
Extracellular: 500-511
Helical: 512-526
Cytoplasmic: 527-536
Helical: 537-557
Extracellular: 558-805
PTM
Palmitoylation is important for expression at the cell membrane and for channel activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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