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Mouse Anti-PKDCC Recombinant Antibody (G-10) (CBMAB-P1922-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase Domain Containing, Cytoplasmic. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PKDCC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
G-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein Kinase Domain Containing, Cytoplasmic
Introduction
PKDCC (Protein Kinase Domain Containing, Cytoplasmic) is a protein coding gene. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and non-membrane spanning protein tyrosine kinase activity.
Entrez Gene ID
91461
UniProt ID
Q504Y2
Alternative Names
SGK493; Vlk
Function
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405).
Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405).
May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity).
Biological Process
Bone mineralizationIEA:Ensembl
Cell differentiationIEA:UniProtKB-KW
Embryonic digestive tract developmentISS:UniProtKB
Limb morphogenesisIEA:Ensembl
Lung alveolus developmentISS:UniProtKB
Multicellular organism growthIEA:Ensembl
Negative regulation of Golgi to plasma membrane protein transportISS:UniProtKB
Peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of bone mineralizationISS:UniProtKB
Positive regulation of chondrocyte differentiationISS:UniProtKB
Protein transportIEA:UniProtKB-KW
Roof of mouth developmentISS:UniProtKB
Skeletal system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted
Golgi apparatus
Involvement in disease
Secreted 1 Publication
Golgi apparatus:
An autosomal recessive skeletal dysplasia characterized by rhizomelic shortening of limbs as well as variable dysmorphic features, including macrocephaly, short neck, micrognathia, mild proptosis, downslanting palpebral fissures, depressed or broad nasal bridge and long philtrum.
PTM
N-glycosylated.
Phosphorylated on tyrosines; probably via autophosphorylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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