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Mouse Anti-PLAU Monoclonal Antibody (3A108) (CBMAB-1692-YC)

Provided herein is a mouse monoclonal antibody against Human PLAU. The antibody, clone 3A108, can be used for immunoassay techniques, such as ELISA and WB.
See all PLAU antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A108
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Full length protein corresponding to Human Urokinase.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
plasminogen activator, urokinase
Introduction
PLAU is a secreted serine protease that converts plasminogen to plasmin. PLAU is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). Mutations in PLAU may be associated with Quebec platelet disorder and late-onset Alzheimer's disease.
Entrez Gene ID
UniProt ID
Alternative Names
ATF; QPD; UPA; URK; u-PA; BDPLT5
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
FibrinolysisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of fibrinolysis1 PublicationIC:ComplexPortal
Negative regulation of plasminogen activation1 PublicationIC:ComplexPortal
Plasminogen activationManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:MGI
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationIEA:Ensembl
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell-matrix adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of wound healing1 PublicationIC:BHF-UCL
Response to hypoxiaIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Smooth muscle cell migrationIEA:Ensembl
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Quebec platelet disorder (QPD):
An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.
PTM
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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