Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848)


See all PLAU antibodies
Online Inquiry
Tested Data
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in ELISA
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in ELISA
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in WB
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in WB
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in WB
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in WB
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in FC
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in FC
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in FC
Mouse Anti-PLAU Recombinant Antibody (CBT4020) (V2LY-0625-LY1848) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4020
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human PLAU (AA: 107-379) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
plasminogen activator, urokinase
Entrez Gene ID
5328
UniProt ID
P00749
Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Biological Process
Blood coagulationIEA:UniProtKB-KW
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
FibrinolysisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of fibrinolysis1 PublicationIC:ComplexPortal
Negative regulation of plasminogen activation1 PublicationIC:ComplexPortal
Plasminogen activationManual Assertion Based On ExperimentIDA:AgBase
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:MGI
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationIEA:Ensembl
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of smooth muscle cell-matrix adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of wound healing1 PublicationIC:BHF-UCL
Response to hypoxiaIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Smooth muscle cell migrationIEA:Ensembl
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
Secreted
Involvement in disease
Quebec platelet disorder (QPD):
An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.
PTM
Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.
Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PLAU Recombinant Antibody (CBT4020)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry