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Mouse Anti-PLCB1 Recombinant Antibody (CBYC-P426) (CBMAB-P2046-YC)

Provided herein is a Mouse monoclonal antibody against Cattle Phospholipase C beta 1. The antibody can be used for immunoassay techniques, such as IP, WB.
See all PLCB1 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle
Clone
CBYC-P426
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Specificity
Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipase C beta 1
Introduction
PLCB1 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals.
Entrez Gene ID
287026
UniProt ID
P10894
Alternative Names
3110043I21Rik; AI132408; Plcb; mKIAA0581
Function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725).
Regulates the function of the endothelial barrier.
Biological Process
Activation of meiosis involved in egg activationISS:BHF-UCL
Cellular response to fluorideIEA:Ensembl
Cellular response to glyceraldehydeIEA:Ensembl
Cellular response to ionomycinIEA:Ensembl
Cellular response to vasopressinIEA:Ensembl
Cerebral cortex developmentISS:BHF-UCL
Fat cell differentiationIEA:Ensembl
G protein-coupled acetylcholine receptor signaling pathwayISS:BHF-UCL
G protein-coupled receptor signaling pathwayTAS:Reactome
G2/M transition of mitotic cell cycleISS:BHF-UCL
Glutamate receptor signaling pathwayISS:BHF-UCL
Inositol trisphosphate metabolic processIEA:Ensembl
Insulin-like growth factor receptor signaling pathwayISS:BHF-UCL
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-12-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-15-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
LearningIEA:Ensembl
MemoryISS:BHF-UCL
Negative regulation of monocyte extravasationISS:BHF-UCL
Negative regulation of transcription, DNA-templatedISS:BHF-UCL
Phosphatidylinositol catabolic processIEA:Ensembl
Phosphatidylinositol metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of acrosome reactionISS:BHF-UCL
Positive regulation of CD24 productionISS:BHF-UCL
Positive regulation of developmental growthISS:BHF-UCL
Positive regulation of embryonic developmentISS:BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycleISS:BHF-UCL
Positive regulation of interleukin-12 productionISS:BHF-UCL
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of myoblast differentiationISS:BHF-UCL
Positive regulation of transcription, DNA-templatedISS:BHF-UCL
Postsynaptic modulation of chemical synaptic transmissionIEA:Ensembl
Regulation of establishment of endothelial barrierIEA:Ensembl
Regulation of fertilizationISS:BHF-UCL
Regulation of G protein-coupled receptor signaling pathwayISS:BHF-UCL
Regulation of retrograde trans-synaptic signaling by endocanabinoidIEA:Ensembl
Signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Nucleus membrane
Cytoplasm
Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Involvement in disease
Developmental and epileptic encephalopathy 12 (DEE12):
A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
PTM
Palmitoylated. Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier. Palmitoylation by ZDHHC21 is stimulated by inflammation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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