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Mouse Anti-PLCB4 Recombinant Antibody (56) (CBMAB-P2050-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipase C beta 4. The antibody can be used for immunoassay techniques, such as WB, IF.
See all PLCB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Fruit fly, Mouse
Clone
56
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Human, Rat, Fruit fly, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phospholipase C beta 4
Introduction
PLCB4 catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina.
Entrez Gene ID
Human5332
Mouse18798
Rat25031
UniProt ID
HumanQ15147
MouseQ91UZ1
RatQ9QW07
Alternative Names
ARCND2; PI-PLC
Function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Biological Process
G protein-coupled receptor signaling pathwayTAS:Reactome
Lipid catabolic processIEA:UniProtKB-KW
Phosphatidylinositol-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytosol
Involvement in disease
Auriculocondylar syndrome 2 (ARCND2):
A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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