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Rabbit Anti-PLEC Recombinant Antibody (D6A11) (CBMAB-CP2019-LY)

The product is antibody recognizes PLEC. The antibody D6A11 immunoassay techniques such as: WB,IP,IF (ICC).
See all PLEC antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D6A11
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu2980 of human plectin-1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Plectin
Entrez Gene ID
Human5339
Mouse18810
Rat64204
Monkey699517
UniProt ID
HumanQ15149
MouseQ9QXS1
RatP30427
MonkeyF7ABN9
Function
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity.
Biological Process
Actin cytoskeleton reorganizationIEA:Ensembl
Actomyosin contractile ring assembly actin filament organizationIEA:Ensembl
Adherens junction organizationIEA:Ensembl
Cardiac muscle cell developmentIEA:Ensembl
Cell morphogenesisIEA:Ensembl
Cellular response to extracellular stimulusIEA:Ensembl
Cellular response to fluid shear stressIEA:Ensembl
Cellular response to hydrostatic pressureIEA:Ensembl
Cellular response to mechanical stimulusIEA:Ensembl
Establishment of skin barrierIEA:Ensembl
Fibroblast migrationIEA:Ensembl
Gene expressionIEA:Ensembl
Hemidesmosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Intermediate filament cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Intermediate filament organizationIEA:Ensembl
Keratinocyte developmentIEA:Ensembl
Leukocyte migration involved in immune responseIEA:Ensembl
Mitochondrion morphogenesisIEA:Ensembl
Multicellular organism growthIEA:Ensembl
Myoblast differentiationIEA:Ensembl
Negative regulation of protein kinase activityIEA:Ensembl
Nucleus organizationIEA:Ensembl
Peripheral nervous system myelin maintenanceIEA:Ensembl
Protein localizationIEA:Ensembl
Protein-containing complex organizationIEA:Ensembl
Regulation of ATP citrate synthase activityIEA:Ensembl
Regulation of vascular permeabilityIEA:Ensembl
Respiratory electron transport chainIEA:Ensembl
Response to foodIEA:Ensembl
Sarcomere organizationIEA:Ensembl
Skeletal muscle fiber developmentIEA:Ensembl
Skeletal myofibril assemblyIEA:Ensembl
T cell chemotaxisIEA:Ensembl
Tight junction organizationIEA:Ensembl
Transmission of nerve impulseIEA:Ensembl
Wound healingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, hemidesmosome
Involvement in disease
Epidermolysis bullosa simplex with pyloric atresia (EBS-PA):
Autosomal recessive genodermatosis characterized by severe skin blistering at birth and congenital pyloric atresia. Death usually occurs in infancy. This disorder is allelic to MD-EBS.
Epidermolysis bullosa simplex, with muscular dystrophy (MD-EBS):
A form of epidermolysis bullosa characterized by the association of blister formation at the level of the hemidesmosome with late-onset muscular dystrophy.
Epidermolysis bullosa simplex, Ogna type (O-EBS):
A form of intraepidermal epidermolysis bullosa characterized by generalized skin bruising, skin fragility with non-scarring blistering and small hemorrhagic blisters on hands. At the ultrastructural level, it is differentiated from classical cases of K-EBS, WC-EBS and DM-EBS, by the occurrence of blisters originating in basal cells above hemidesmosomes, and abnormal hemidesmosome intracellular attachment plates.
Muscular dystrophy, limb-girdle, autosomal recessive 17 (LGMDR17):
A form of limb-girdle muscular dystrophy characterized by early childhood onset of proximal muscle weakness. Limb-girdle muscular dystrophies are characterized by proximal weakness, weakness of the hip and shoulder girdles and prominent asymmetrical quadriceps femoris and biceps brachii atrophy.
Epidermolysis bullosa simplex with nail dystrophy (EBSND):
A form of epidermolysis bullosa, a dermatologic disorder characterized by skin blistering. EBSND patients also manifest nail dystrophy.
PTM
Phosphorylated by CDK1; regulates dissociation from intermediate filaments during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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