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Mouse Anti-PLRG1 Recombinant Antibody (7H2) (CBMAB-P2174-YC)

Provided herein is a Mouse monoclonal antibody against Human Pleiotropic Regulator 1. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all PLRG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7H2
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PLRG1 (NP_002660, 101-198 aa) partial recombinant protein with GST tag. Immunogen sequence: PPGPGVALTA DTKIQRMPSE SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK KAPTMPKPQW HPPWKLYR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 101-198

Target

Full Name
pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
Introduction
PLRG1 is a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection.
Entrez Gene ID
5356
UniProt ID
O43660
Alternative Names
PRPF46; PRP46; PRL1; TANGO4; Cwc1
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346).
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).
Biological Process
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of G1/S transition of mitotic cell cycleIEA:Ensembl
Protein localization to nucleusIEA:Ensembl
Cellular Location
Nucleus
Nucleus speckle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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