Mouse Anti-PLXND1 Recombinant Antibody (CBYC-P470) (CBMAB-P2212-YC)

Name: Mouse Anti-PLXND1 Recombinant Antibody (CBYC-P470)
SKU: CBMAB-P2212-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYC-P470

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Plexin D1

Introduction

PLXND1 (Plexin D1) is a protein coding gene. Diseases associated with PLXND1 include Moebius Syndrome and Conotruncal Heart Malformations. Among its related pathways areDevelopmental Biology and Semaphorin interactions. Gene Ontology annotations related to this gene include semaphorin receptor activity. An important paralog of the gene is PLXNB1.

Entrez Gene ID

23129

UniProt ID

Q9Y4D7

Alternative Names

PLEXD1

Function

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity).
Mediates anti-angiogenic signaling in response to SEMA3E.

Biological Process

AngiogenesisISS:UniProtKB
Aorta developmentIEA:Ensembl
Branching involved in blood vessel morphogenesisIEA:Ensembl
Cardiac septum developmentIEA:Ensembl
Coronary vasculature developmentIEA:Ensembl
Dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Endothelial cell migrationISS:UniProtKB
Kidney developmentIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron apoptotic processIEA:Ensembl
Outflow tract morphogenesisIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein bindingIEA:Ensembl
Regulation of angiogenesisISS:UniProtKB
Regulation of cell migrationISS:UniProtKB
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathwayISS:UniProtKB
Semaphorin-plexin signaling pathway involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Synapse assemblyISS:UniProtKB

Cellular Location

Cell membrane
Cell projection, lamellipodium membrane

Topology

Extracellular: 47-1271
Helical: 1272-1292
Cytoplasmic: 1293-1925

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-PLXND1 Recombinant Antibody (CBYC-P471) (CAT#: CBMAB-P2213-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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