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Mouse Anti-PMCH Recombinant Antibody (1D1) (CBMAB-P2216-YC)

Provided herein is a Mouse monoclonal antibody against Human Pro-Melanin Concentrating Hormone. The antibody can be used for immunoassay techniques, such as WB, IP, ELISA.
See all PMCH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D1
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pro-melanin-concentrating hormone
Introduction
PMCH is a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep.
Entrez Gene ID
UniProt ID
Alternative Names
MCH; ppMCH
Function
MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Chemical synaptic transmissionIEA:InterPro
Feeding behaviorISS:UniProtKB
Neuropeptide signaling pathwayIEA:UniProtKB-KW
SpermatogenesisIEA:UniProtKB-KW
Cellular Location
Secreted
PTM
Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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