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Mouse Anti-PMP2 Recombinant Antibody (11n70) (CBMAB-P2235-YC)

Provided herein is a Mouse monoclonal antibody against Human Peripheral Myelin Protein 2. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all PMP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11n70
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Recombinant corresponding to AA 2-132 from human FABP8/M-FABP expressed in E. coli (P02689).
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 2-132

Target

Full Name
Peripheral Myelin Protein 2
Introduction
PMP2 localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy.
Entrez Gene ID
5375
UniProt ID
P02689
Alternative Names
P2; MP2; M-FABP; FABP8
Function
May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
Biological Process
Fatty acid transportManual Assertion Based On ExperimentIBA:GO_Central
Membrane organizationIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Charcot-Marie-Tooth disease, demyelinating, 1G (CMT1G):
An autosomal dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1G is characterized by distal muscle weakness and atrophy with onset in the first or second decade.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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