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Mouse Anti-PMP22 Recombinant Antibody (3G10) (CBMAB-P2237-YC)

Provided herein is a Mouse monoclonal antibody against Human Peripheral Myelin Protein 22. The antibody can be used for immunoassay techniques, such as ELISA.
See all PMP22 antibodies
Published Data
Fig.1 The expression level of PMP22 in CML cell line K562.
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Fig.2 Flow cytometry displayed the cell apoptosis of different groups.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peripheral myelin protein 22
Introduction
PMP22 is an integral membrane protein that is a major component of myelin in the peripheral nervous system. Studies suggest two alternately used promoters drive tissue-specific expression. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies.
Entrez Gene ID
5376
UniProt ID
Q01453
Alternative Names
HNPP; HMSNIA; CMT1E; DSS; CMT1A; Sp110; GAS-3; CIDP; GAS3
Function
Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Biological Process
Bleb assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiationIEA:Ensembl
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Myelin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of neuron projection developmentIEA:Ensembl
Peripheral nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Charcot-Marie-Tooth disease 1A (CMT1A):
A dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
Dejerine-Sottas syndrome (DSS):
A severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. Characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
Hereditary neuropathy with liability to pressure palsies (HNPP):
A neurologic disorder characterized by transient episodes of decreased perception or peripheral nerve palsies after slight traction, compression or minor traumas.
Charcot-Marie-Tooth disease 1E (CMT1E):
An autosomal dominant form of Charcot-Marie-Tooth disease characterized by the association of sensorineural hearing loss with peripheral demyelinating neuropathy.
Inflammatory demyelinating polyneuropathy (IDP):
Putative autoimmune disorder presenting in an acute (AIDP) or chronic form (CIDP). The acute form is also known as Guillain-Barre syndrome.
Topology
Cytoplasmic: 1
Helical: 2-31
Extracellular: 32-64
Helical: 65-91
Cytoplasmic: 92-95
Helical: 96-119
Extracellular: 120-133
Helical: 134-156
Cytoplasmic: 157-160
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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