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Mouse Anti-PNLIPRP2 Recombinant Antibody (4F10) (CBMAB-P2255-YC)

Provided herein is a Mouse monoclonal antibody against Human Pancreatic Lipase Related Protein 2. The antibody can be used for immunoassay techniques, such as ELISA.
See all PNLIPRP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F10
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
pancreatic lipase-related protein 2
Introduction
PNLIPRP2 is a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele.
Entrez Gene ID
5408
UniProt ID
P54317
Alternative Names
PLRP2
Function
Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:19451396, PubMed:21865348, PubMed:20083229, PubMed:26494624, PubMed:18702514).
In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23732775, PubMed:19824014, PubMed:21652702).
Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:21865348, PubMed:21652702, PubMed:18702514).
Can completely deacylate triacylglycerols (PubMed:21865348).
When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:20083229, PubMed:26494624, PubMed:18702514).
Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:20083229, PubMed:18702514).
May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775).
Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775).
In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity).
Also has low phospholipase activity (PubMed:17401110, PubMed:18702514).
In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity).
The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Biological Process
Galactolipid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Lipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid digestionTAS:Reactome
Phosphatidylcholine catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Triglyceride catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Triglyceride metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Zymogen granule membrane
Cell projection, neuron projection
Localizes to neurite tips in neuronal cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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