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Mouse Anti-PNPLA2 Recombinant Antibody (AT2G2) (CBMAB-A4669-YC)

Provided herein is a Mouse monoclonal antibody against Human Patatin like phospholipase domain containing 2. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA.
See all PNPLA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AT2G2
Antibody Isotype
IgG2b
Application
WB, FC, ELISA

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
patatin-like phospholipase domain containing 2
Introduction
PNPLA2 is an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
Entrez Gene ID
Human57104
Mouse66853
UniProt ID
HumanQ96AD5
MouseQ8BJ56
Alternative Names
ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
Function
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821, PubMed:17603008, PubMed:16239926).
Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity).
Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008).
Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008).
Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926).
May play an important role in energy homeostasis (By similarity).
May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity).
Biological Process
Acylglycerol acyl-chain remodelingTAS:Reactome
Diacylglycerol biosynthetic processISS:UniProtKB
Lipid droplet disassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Lipid homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Lipid storageIEA:Ensembl
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of triglyceride catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Triglyceride catabolic processISS:UniProtKB
Cellular Location
Lipid droplet
Cell membrane
Cytoplasm
Involvement in disease
Neutral lipid storage disease with myopathy (NLSDM):
Neutral lipid storage disorder (NLSD) with myopathy but without ichthyosis. NLSDs are characterized by the presence of triglyceride-containing cytoplasmic droplets in leukocytes and in other tissues, including bone marrow, skin, and muscle. Individuals with NLSDM did not show obesity, in spite of a defect in triglyceride degradation in fibroblasts and in marked triglyceride storage in liver, muscles, and other visceral cells.
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-42
Helical: 43-63
Cytoplasmic: 64-137
Helical: 138-158
Extracellular: 159-329
Helical: 330-350
Cytoplasmic: 351-504
PTM
Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity).
Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation (PubMed:22733971).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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