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Mouse Anti-PNPO Recombinant Antibody (1G9) (CBMAB-P2278-YC)

Provided herein is a Mouse monoclonal antibody against Human Pyridoxamine 5'-Phosphate Oxidase. The antibody can be used for immunoassay techniques, such as WB, FC, IHC.
See all PNPO antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G9
Antibody Isotype
IgG2a
Application
WB, FC, IHC

Basic Information

Immunogen
Full length human recombinant protein of human PNPO (NP_060599) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pyridoxamine 5'-Phosphate Oxidase
Introduction
PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.
Entrez Gene ID
55163
UniProt ID
Q9NVS9
Alternative Names
HEL-S-302; PDXPO
Function
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Biological Process
Pyridoxal phosphate biosynthetic processManual Assertion Based On ExperimentIDA:CAFA
Pyridoxine biosynthetic processIEA:UniProtKB-KW
Cellular Location
Cytosol
Involvement in disease
Pyridoxine-5'-phosphate oxidase deficiency (PNPOD):
The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine,.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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