Sign in or Register   Sign in or Register
  |  

Rabbit Anti-POLR1A Recombinant Antibody (CBYC-P500) (CBMAB-P2338-YC)

Provided herein is a Rabbit monoclonal antibody against Human RNA Polymerase I Subunit A. The antibody can be used for immunoassay techniques, such as WB, ChIP.
See all POLR1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey
Clone
CBYC-P500
Antibody Isotype
IgG
Application
WB, ChIP

Basic Information

Specificity
Human, Mouse, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA Polymerase I Subunit A
Introduction
POLR1A is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis.
Entrez Gene ID
Human25885
Mouse20019
Monkey696963
UniProt ID
HumanO95602
MouseO35134
MonkeyF7AG21
Alternative Names
A190; AFDCIN; RPA1; RPA194; RPO1-4; RPO14
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
Biological Process
Negative regulation of protein localization to nucleolusManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Nucleus, nucleolus
Chromosome
Involvement in disease
Acrofacial dysostosis, Cincinnati type (AFDCIN):
A form of acrofacial dysostosis, a group of disorders which are characterized by malformation of the craniofacial skeleton and, in some patients, the limbs.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-POLR1A Recombinant Antibody (CBYC-P500)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare