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Recombinant Mouse Anti-POLR1B Recombinant Antibody (2D3) (CBMAB-XB0937-YC)

Provided herein is a Mouse Recombinant Antibody against RNA Polymerase I Subunit B. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all POLR1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D3
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Synthetic peptide: (C)-YGIPREQQKAALQELTRAHVES corresponding to aa 24 to 45 of human Polymerase I (Polypeptide B).
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
polymerase (RNA) I polypeptide B, 128kDa
Introduction
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast.
Entrez Gene ID
84172
UniProt ID
Q9H9Y6
Alternative Names
RPA2; RPA135; Rpo1-2
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
Biological Process
Embryo implantationIEA:Ensembl
Neural crest formationISS:UniProtKB
NucleologenesisIEA:Ensembl
rRNA transcriptionIEA:Ensembl
Cellular Location
Nucleus, nucleolus
Chromosome
Involvement in disease
Treacher Collins syndrome 4 (TCS4):
A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. TCS4 inheritance pattern is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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