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Mouse Anti-POLR2G Recombinant Antibody (CBYC-P504) (CBMAB-P2357-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P504
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Immunogen
Recombinant human RNA Polymerase II, DNA-directed, Polypeptide G
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA Polymerase II Subunit G
Introduction
POLR2G is the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation.
Entrez Gene ID
5436
UniProt ID
P62487
Alternative Names
hsRPB7; RPB7; hRPB19; RPB19
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).
Binds RNA.
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolyticManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of nuclear-transcribed mRNA poly(A) tail shorteningManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translational initiationManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Transcription initiation from RNA polymerase II promoterManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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