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Mouse Anti-POLR2M Recombinant Antibody (CBLG1-2406) (CBMAB-G6469-LY)

This product is antibody recognizes POLR2M. The antibody CBLG1-2406 immunoassay techniques such as: ELISA, WB.
See all POLR2M antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2406
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant (aa269-369) from human GRINL1A (NP_056347) with GST tag. MW of the GST tag alone is 26 KDa.ImmunogenType: Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RNA Polymerase II Subunit M
Introduction
This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781.
Entrez Gene ID
UniProt ID
Alternative Names
GCOM1; GRINL1A; Gdown; Gdown1
Function
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Biological Process
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Maintenance of ER locationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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