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Mouse Anti-POLR3H Recombinant Antibody (5A12) (CBMAB-P2377-YC)

Provided herein is a Mouse monoclonal antibody against Human RNA Polymerase III Subunit H. The antibody can be used for immunoassay techniques, such as WB.
See all POLR3H antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5A12
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human POLR3H (NP_612211) produced in E. coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
RNA Polymerase III Subunit H
Introduction
POLR3H (RNA Polymerase III Subunit H) is a protein coding gene. Diseases associated with POLR3H include Optic Atrophy 9 and Infantile Cerebellar-Retinal Degeneration. Among its related pathways are RNA Polymerase III Transcription Initiation and Pyrimidine metabolism (KEGG). Gene Ontology annotations related to this gene include DNA-directed 5-3 RNA polymerase activity and RNA polymerase III activity.
Entrez Gene ID
171568
UniProt ID
Q9Y535
Alternative Names
RPC22.9; RPC8
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Biological Process
Defense response to virusIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Transcription by RNA polymerase IIIManual Assertion Based On ExperimentIDA:UniProtKB
Transcription initiation from RNA polymerase III promoterManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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