Rabbit Anti-POMP Recombinant Antibody (CBYC-P513) (CBMAB-P2395-YC)

Name: Rabbit Anti-POMP Recombinant Antibody (CBYC-P513)
SKU: CBMAB-P2395-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBYC-P513

Application

WB, IP

Specificity

Human, Mouse, Rat, Monkey, Cattle

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Proteasome Maturation Protein

Introduction

POMP is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.

Entrez Gene ID

Human	51371
Mouse	66537
Rat	288455
Cattle	510314
Monkey	711980

UniProt ID

Human	Q9Y244
Mouse	Q9CQT5
Rat	A5HKJ3
Cattle	Q3SZV5
Monkey	H9FVG5

Alternative Names

C13orf12; HSPC014; PNAS-110; UMP1

Function

Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.

Biological Process

Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytosol
Nucleus
Microsome membrane

Involvement in disease

Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK):
A keratinizing disorder characterized by ichthyosis, palmoplantar keratoderma with constricting bands around fingers, flexural deformities of fingers and keratotic papules in a linear distribution on the flexural side of large joints. Histological examination of the skin of affected individuals shows hypertrophy and hyperplasia of the spinous, granular and horny epidermal layer.
Proteasome-associated autoinflammatory syndrome 2 (PRAAS2):
Proteasome-associated autoinflammatory syndrome 2 (PRAAS2)

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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