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Rabbit Anti-POMP Recombinant Antibody (CBYC-P513) (CBMAB-P2395-YC)

Provided herein is a Rabbit monoclonal antibody against Human Proteasome Maturation Protein. The antibody can be used for immunoassay techniques, such as WB, IP.
See all POMP antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle
Clone
CBYC-P513
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Proteasome Maturation Protein
Introduction
POMP is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.
Entrez Gene ID
Human51371
Mouse66537
Rat288455
Cattle510314
Monkey711980
UniProt ID
HumanQ9Y244
MouseQ9CQT5
RatA5HKJ3
CattleQ3SZV5
MonkeyH9FVG5
Alternative Names
C13orf12; HSPC014; PNAS-110; UMP1
Function
Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.
Biological Process
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytosol
Nucleus
Microsome membrane
Involvement in disease
Keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK):
A keratinizing disorder characterized by ichthyosis, palmoplantar keratoderma with constricting bands around fingers, flexural deformities of fingers and keratotic papules in a linear distribution on the flexural side of large joints. Histological examination of the skin of affected individuals shows hypertrophy and hyperplasia of the spinous, granular and horny epidermal layer.
Proteasome-associated autoinflammatory syndrome 2 (PRAAS2):
Proteasome-associated autoinflammatory syndrome 2 (PRAAS2)
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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