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Mouse Anti-POR Recombinant Antibody (CBYY-C2726) (CBMAB-C4167-YY)

This product is mouse antibody that recognizes POR. The antibody CBYY-C2726 can be used for immunoassay techniques such as: FC, IF, IHC-P, WB
See all POR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2726
Antibody Isotype
IgG2a
Application
FC, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Preservative
50% glycerol, 1% BSA, PBS, pH 7.3
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytochrome P450 Oxidoreductase
Entrez Gene ID
5447
UniProt ID
P16435
Alternative Names
Integrin Subunit Alpha M
Function
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Biological Process
Carnitine metabolic processIEA:Ensembl
Cellular organofluorine metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to follicle-stimulating hormone stimulusIEA:Ensembl
Cellular response to peptide hormone stimulusIEA:Ensembl
DemethylationIEA:Ensembl
Electron transport chainManual Assertion Based On ExperimentIDA:UniProtKB
Fatty acid oxidationIEA:Ensembl
Flavonoid metabolic processIEA:Ensembl
Internal peptidyl-lysine acetylationIEA:Ensembl
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA:Ensembl
Negative regulation of lipase activityIEA:Ensembl
Nitrate catabolic processIEA:Ensembl
Nitric oxide catabolic processIEA:Ensembl
Positive regulation of cholesterol biosynthetic processIEA:Ensembl
Positive regulation of chondrocyte differentiationIEA:Ensembl
Positive regulation of monooxygenase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of smoothened signaling pathwayIEA:Ensembl
Positive regulation of steroid hormone biosynthetic processIEA:Ensembl
Regulation of growth plate cartilage chondrocyte proliferationIEA:Ensembl
Response to dexamethasoneIEA:Ensembl
Response to hormoneManual Assertion Based On ExperimentIBA:GO_Central
Response to nutrientIEA:Ensembl
Xenobiotic metabolic processTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Antley-Bixler syndrome, with genital anomalies and disordered steroidogenesis (ABS1):
A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures.
Disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD):
A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
Topology
Lumenal: 2-21
Helical: 22-42
Cytoplasmic: 43-677
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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